Wednesday, September 29, 2010


Ethan's chiimerisms are down to 13% donor. Dr. Nemecek is officially saying that the bone marrow engraftment has failed and we're going to a second transplant, probably in January. 

The initial donor search has been done. There are a good number of 6/6 adult donor matches and one 6/6 cord blood match. Six out of six is considered a perfect match. However there are an additional six markers that they will try to match. They are starting to call in adult donors to do a screen on that second set of markers. 

Ethan's first transplant was a reduced toxicity regime in an effort to reduce the chance of mortality from the regime itself. Reduced toxicity regimes don't seek to remove all of the host bone marrow, only enough to clear out enough space for the donor cells. This second transplant will be a full ablative, full toxicity regime. 

The risks are significant. Typical mortality on these transplants is 30%. But Ethan is a very strong little boy, and I'm hopeful and confident that his odds are better than that.

It's a long time between now and January, and there will be more to share and talk about over the coming months.

In the meantime, we will play and learn and enjoy.

Love to you all,
Todd, Sarah, Caleb and Ethan 

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